Later that year, the Aerosmith compilation Devil’s Got a New Disguise was released, which included two new tracks. Tyler hit the road with Aerosmith again for the Route of All Evil Tour with Mötley Crüe and also made several more public appearances. He made a cameo appearance on the sitcom Two and a Half Men, playing himself. On October 14, 2006, Tyler sang “God Bless America” during the seventh inning stretch at Game No.3 of the National League Championship Seriesbetween the St. Louis Cardinals and the New York Mets at Busch Stadium in St. Louis. On November 24, he volunteered by serving Thanksgiving dinner to the needy at a restaurant in West Palm Beach, Florida, before an Aerosmith show there.In 2007, Tyler kept active in Aerosmith with the band’s world tour which saw them perform in 19 countries. Also that year, Tyler and daughter Liv were profiled on E! True Hollywood Story.
On May 21, 2008, Tyler checked into Las Encinas Hospital rehabilitation clinic in Pasadena, California, to recover from multiple leg surgeries. He made a public statement saying that “The ‘foot repair’ pain was intense, greater than I’d anticipated. The months of rehabilitative care and the painful strain of physical therapy were traumatic. I really needed a safe environment to recuperate where I could shut off my phone and get back on my feet.” In June 2008, Guitar Hero: Aerosmith was released, the franchise’s first video game based solely around one band and the most successful game based around a band. On July 14, 2008, Tyler’s mother, Susan Rey Tallarico, died at the age of 84. On July 18, 2008, Steven Tyler appeared with Billy Joel at the last concert to be played at Shea Stadium. Backed by Joel’s band, he sang lead vocals on “Walk This Way“. In August 2008 HarperCollins won an auction to publish Tyler’s autobiography.That same month, Tyler performed with trumpeter Chris Botti in Boston. In December 2008, Tyler made a surprise appearance at the Trans-Siberian Orchestra concerts at Nassau Coliseum (December 12, 2008) and the Izod Center (December 13, 2008). At the Izod Center, he collaborated with the Trans-Siberian Orchestra on “Dream On” and “Sweet Emotion”.