Antwerp is a city in Belgium which is the capital of Antwerp province. With a population of 510,610, it is the most populous city in Flanders. Its metropolitan area houses around 1,200,000 people.Antwerp is on the River Scheldt, linked to the North Sea by the Westerschelde estuary. The Port of Antwerp is one of the biggest in the world, ranking third in Europe and within the top 20 globally.Antwerp has long been an important city in the Low Countries, both economically and culturally, especially before the Spanish Fury (1576) in the Dutch Revolt. The inhabitants of Antwerp are nicknamed Sinjoren, after the Spanish honorific señor or French seigneur, „lord”, referring to the Spanish noblemen who ruled the city in the 17th century.